Neuropeptide Y (NPY) is a 36-amino acid peptide that acts as a neurotransmitter in the brain and in the autonomic nervous system. In the brain NPY is produced in various locations and is hypothesized to have several important functions, for example, regulation of appetite, reducing anxiety and stress, reducing pain perception and controlling epileptic seizures. The mechanism for its effect on epileptic seizures is that NPY inhibits the transsynaptic release of glutamate, which is an excitatory neurotransmitter.
CombiGene’s scientific founders were among the first in the world to show that NPY inhibit epileptic seizures in animals, and that this effect is further enhanced if the NPY receptor Y2 is also upregulated.
Read more about NPY and Y2’s inhibitory effect on epileptic seizures: